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September 5, 2025Pharmacy EducationOpen Access

Virtual screening of metabolites from mulberry (Morus alba L.) leaves as anti-hyperglycemic agents through molecular docking against multiple targets

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Authors

WPWimzy Rizqy PrabhataGPGinanjar PratamaSKShilvia Anggun Tiara Kaldella

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Overview

Molecular docking identifies metabolites from mulberry leaves as promising anti-hyperglycemic agents, implying the need for further bioavailability studies.

Key Points

  • Sixteen compounds showed top docking scores against 12 targets related to hyperglycemia, indicating potential efficacy.
  • Sanggenol M ranked high against 7 targets including alpha-glucosidase and glucagon receptor, highlighting its multi-target potential.
  • Analysis based on Lipinski’s rule and BOILED-Egg diagram suggested Sanggenol M has poor oral bioavailability, demanding further development.
  • The study utilized molecular docking to screen 157 metabolites, emphasizing in silico approaches for drug discovery.

Cite This Study

Prabhata et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d276d6d5674bcd013a7https://doi.org/10.46542/pe.2025.252.814
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Network Pharmacology Prediction and Metabolomics Validation of the Novel Targets of Morus alba L. against High-Fat Diet-Induced Diabetes Mellitus in C57/6J Mice2024 · 4 citations
  2. 2Insilico Studies Unveiling the Hepatoprotective Potential of Morus alba Linn: Docking and ADMET Analysis2024
  3. 3Discovery of vitexin as a novel α‐glucosidase inhibitors in mulberry (<i>Morus alba</i> L.) by untargeted metabolomics combined with molecular docking: A comprehensive study from mechanism to synergy effects2024 · 3 citations
  4. 4Use of Mulberry for the Pharmaceutical Sector: Phytochemistry, Pharmacological Potential and Translational Perspectives2026
  5. 5Elucidating Key Components and Mechanisms Underlying the Synergistic Anti-Type 2 Diabetes Effect of Morus alba L. and Siraitia grosvenorii Combination: An Integrated In Vitro Enzymology, Untargeted Metabolomics, and Network Pharmacology Approach2025