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September 10, 2025AntioxidantsOpen Access

Elucidating Key Components and Mechanisms Underlying the Synergistic Anti-Type 2 Diabetes Effect of Morus alba L. and Siraitia grosvenorii Combination: An Integrated In Vitro Enzymology, Untargeted Metabolomics, and Network Pharmacology Approach

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Authors

FHFang HeSSS S SuRSRuihan Song

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Overview

This study evaluates the combined anti-diabetic effects of Morus alba L. and Siraitia grosvenorii on T2DM, suggesting a strong synergistic potential.

Key Points

  • Morus alba L. and Siraitia grosvenorii significantly enhance each other's anti-diabetes effects, showing a greater inhibition than individual extracts.
  • The combination of Morus alba L. and Siraitia grosvenorii achieved a notable IC50 of 14.06 mg/mL for α-amylase and 0.02 mg/mL for α-glucosidase.
  • In vitro assays revealed MLSG's superior antioxidant activities, indicating its potential for T2DM management.
  • Network pharmacology identified key targets like STAT3 and AKT1, highlighting the multi-target mechanism of this combination.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/68c1d7f654b1d3bfb60fa162https://doi.org/10.3390/antiox14091065
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antidiabetic activity of Siraitia grosvenorii, Dimocarpus longan Lour. and Orthosiphon stamineus Benth. Extracts combinations in vitro and in silico2024 · 7 citations
  2. 2A Combined Probiotic-Morus alba Strategy Enhances Glucose Homeostasis in an In Vitro Gut-Pancreas-Liver Axis Model: A Preliminary Mechanistic Screening Study2026 · 2 citations
  3. 3Virtual screening of metabolites from mulberry (Morus alba L.) leaves as anti-hyperglycemic agents through molecular docking against multiple targets2025
  4. 4Network Pharmacology Prediction and Metabolomics Validation of the Novel Targets of Morus alba L. against High-Fat Diet-Induced Diabetes Mellitus in C57/6J Mice2024 · 4 citations
  5. 5The Synergistic Enhancement of Anti-Metabolic Diseases Function of Morus alba with the Combination of Cha (Camellia sinensis)2024