What does this research mean for the field?

A combination of Psidium guajava and Seriphium plumosum extracts synergistically enhances glucose uptake and glycogen storage while reducing hepatic GLUT2 expression in in vitro models of hepatic and skeletal muscle tissue. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the individual and combined effects of Psidium guajava and Seriphium plumosum extracts on glucose metabolism, GLUT2 expression, and cellular energy status in liver and muscle models.

September 8, 2026NutrientsOpen Access

A Combination of Psidium guajava and Seriphium plumosum Modulates Glucose Metabolism and Reduces Hepatic GLUT2 Expression Through Additive-to-Synergistic Interactions

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Authors

NTNokukhanya ThembaneMangosuthu University of Technology SSSiboniso SitholeUniversity of KwaZulu-Natal SHSphamandla HlatshwayoUniversity of KwaZulu-Natal

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Implication

In vitro study reveals synergistic enhancement of glucose uptake and reduced GLUT2 expression in liver and muscle cells, suggesting potential utility for metabolic dysfunction.

Key Points

To evaluate the individual and combined effects of Psidium guajava and Seriphium plumosum extracts on glucose metabolism, GLUT2 expression, and cellular energy status in liver and muscle models.
Treated HepG2 hepatocytes and differentiated C2C12 myotubes with Psidium guajava (PG), Seriphium plumosum (SP), and a 1:1 PG+SP combination.
Assessed cell viability, glucose uptake, GLUT2 expression, glycogen content, and AMP levels across treatment groups.
Quantified drug interactions using Bliss Independence, Combination Index (CI), Loewe Additivity, and Zero Interaction Potency (ZIP) models.
The PG+SP combination exhibited additive-to-synergistic interactions (CI = 0.51–0.89) and significantly enhanced HepG2 glucose uptake (p < 0.05), reaching approximately 94% of the response elicited by metformin.
Hepatic GLUT2 expression was significantly downregulated by the PG+SP combination, showing the largest reduction at 125 + 125 µg/mL (0.77 ± 0.14-fold, p < 0.0001).
In C2C12 myotubes, PG, SP, and PG+SP significantly increased glucose uptake and glycogen accumulation (p < 0.05), with the combination lowering AMP levels below control values.

Cite This Study

Thembane et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd82058e84d0ff5b476d8 https://doi.org/10.3390/nu18172920

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Implication

In vitro study reveals synergistic enhancement of glucose uptake and reduced GLUT2 expression in liver and muscle cells, suggesting potential utility for metabolic dysfunction.

A Combination of Psidium guajava and Seriphium plumosum Modulates Glucose Metabolism and Reduces Hepatic GLUT2 Expression Through Additive-to-Synergistic Interactions

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Implication

Key Points

Cite This Study

A Combination of Psidium guajava and Seriphium plumosum Modulates Glucose Metabolism and Reduces Hepatic GLUT2 Expression Through Additive-to-Synergistic Interactions

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Implication

Key Points

Cite This Study

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