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September 5, 2025Open Access

Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinoma

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Authors

KSKuniaki SatoNKNoritaka KomuneMOMayumi Ono

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Overview

Comprehensive analysis reveals YAP/TEAD signaling's impact on transcriptional reprogramming in EACSCC, suggesting new therapeutic targets.

Key Points

  • Hyperactivation of YAP/TEAD signaling correlates with malignant transformation in EACSCC.
  • TEAD inhibitors significantly suppressed EACSCC cell proliferation and clonogenicity in vitro.
  • EACSCC tissues showed elevated PITX2 expression, linked to poor prognosis and tumor growth.
  • Identified super enhancers highlight potential therapeutic targets in treating EACSCC.

Cite This Study

Sato et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d276d6d5674bcd0140bhttps://doi.org/10.1101/2025.08.27.672711
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinoma2026
  2. 2O6 Dissecting the shift in YAP/TAZ signalling modalities with disease progression in cancer-associated fibroblasts of cutaneous squamous cell carcinoma2026
  3. 3Abstract 1707: YAP-driven epigenetic reprogramming in head and neck cancer2024
  4. 4Abstract 2663: Targeting YAP/TEAD signaling disturbs RNA polymerase II activity and enhances immunotherapy response via activated cytosolic DNA sensing pathway in gastroesophageal cancer2026
  5. 5DECODING YAP-DRIVEN MALIGNANT REPROGRAMMING IN ORAL EPITHELIAL STEM CELLS THROUGH SINGLE-CELL ANALYSIS2025