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September 5, 2025Updates in SurgeryOpen Access

Predictive factors for long-term survival in pancreatic ductal adenocarcinoma that underwent surgery: a systematic review and meta-analysis of literature

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Authors

VDVincenzo D’AmbraCRClaudio RicciCICarlo Ingaldi

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Overview

Systematic review identifies clinic-pathological and molecular factors for long-term survival in PDAC patients, suggesting new predictive markers.

Key Points

  • Long-term survival rates increase with smaller tumor size, T1-T2 stage, and R0 resection status.
  • Study analyzed 19 studies involving 5412 patients, with 20.3% categorized as long-term survivors.
  • Meta-analysis utilized random effects model to assess risk ratios and mean differences among predictive factors.
  • Findings highlight significant associations of clinic-pathological factors that may aid in predicting tumor progression.

Cite This Study

D’Ambra et al. (2025) studied this question.

synapsesocial.com/papers/68bb4d2d6d6d5674bcd014behttps://doi.org/10.1007/s13304-025-02382-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poor Prognostic Factors in Long-Term Survivors of Resected Pancreatic Ductal Adenocarcinoma2024 · 10 citations
  2. 2Prognostic factors for resectable pancreatic adenocarcinoma: a systematic review and meta-analysis2026
  3. 3Prognostic Determinants of Overall Survival After Resection for Pancreatic Ductal Adenocarcinoma: A Consensus‐Based Conceptual Framework2026
  4. 4Predictive factors of early recurrence of pancreatic adenocarcinoma after curative resection surgery2024
  5. 5Preoperative Prediction of Long-Term Survival After Surgery in Patients with Resectable Pancreatic Ductal Adenocarcinoma2024 · 6 citations