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September 5, 2025VirusesOpen Access

Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes

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Authors

RMRashid MirFahd bin Sultan UniversityMUMohammad Fahad UllahUniversity of TabukIEImadeldin ElfakiUniversity of Khartoum

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Overview

Pilot study uncovers rare genetic variants affecting SARS-CoV-2 susceptibility in patients, highlighting comorbidity implications.

Key Points

  • Identified 4478 rare genetic variants in Saudi COVID-19 patients, with significant links to disease severity.
  • Higher mortality rates were observed in male patients, particularly those with comorbid conditions like T2DM and hypertension.
  • Analysis revealed numerous missense and frameshift variants across key genes involved in immune response.
  • Findings suggest that certain variants may be unique to the regional population, warranting further large-scale investigations.

Cite This Study

Mir et al. (2025) studied this question.

synapsesocial.com/papers/68bb4de86d6d5674bcd01919https://doi.org/10.3390/v17091198
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