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September 5, 2025Frontiers in Bioscience-LandmarkOpen Access

Antioxidant Cardioprotection in Acute Myocardial Infarction: From Mechanisms to Therapeutic Strategies

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Authors

EVEduardo VillaLSLuciano SasoSCSilvia Chichiarelli

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Overview

Review unveils mechanisms of oxidative stress in AMI, highlighting antioxidant strategies to reduce reperfusion injury.

Key Points

  • Antioxidants may alleviate myocardial reperfusion injury after acute myocardial infarction, enhancing treatment outcomes.
  • Up to 50% of final infarct size can result from reperfusion injury, emphasizing the role of oxidative stress.
  • Numerous antioxidant strategies demonstrate promise in preclinical settings, yet limited effectiveness is observed in humans.
  • Combining multiple cardioprotective interventions may yield improved results in mitigating oxidative damage post-AMI.

Cite This Study

Villa et al. (2025) studied this question.

synapsesocial.com/papers/68bb4de86d6d5674bcd01b64https://doi.org/10.31083/fbl27678
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  1. 1Oxidative Stress and Inflammation in Myocardial Ischemia–Reperfusion Injury: Protective Effects of Plant‐Derived Natural Active Compounds2024 · 13 citations
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  3. 3Pharmacological Strategies to Contend Against Myocardial Reperfusion Damage: Diverse Chemicals for Multiple Targets2010 · 7 citations
  4. 4Cardioprotection and pharmacological therapies in acute myocardial infarction: Challenges in the current era2014 · 43 citations
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