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September 5, 2025Journal of ObesityOpen Access

MRI‐Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites

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Genetically higher abdominal subcutaneous adipose tissue is linked to an adverse metabolic profile and increased risk of type 2 diabetes.
The study identified distinct genetic loci related to 10 different fat depots, significantly highlighting differences in disease risks.
Using MRI data from the UK Biobank, the analysis involved 37,589 participants and assessed various health outcomes.
Higher thigh subcutaneous adipose tissue was associated with lower risks of type 2 diabetes and improved cardiovascular outcomes.

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Analysis of MRI data reveals associations between fat distribution and type 2 diabetes, suggesting depot-specific health implications.

Ahmed et al. (2025) studied this question.

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