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Analysis reveals acute pain alters EEG activity in rats under urethane anesthesia, suggesting implications for pain treatment.
Certain neurophysiological mechanisms of pain can be investigated in anesthetized animals, and such a model is potentially useful for the development of pain treatment. Yet, the interference of pain-related neural patterns and anesthesia-related patterns should be understood. Here we studied he interplay between acute pain-induced and urethane-induced EEG activity. We analyzed the activity of the rats' somatosensory cortex under urethane-induced anesthesia both before and after introducing a painful stimulus (formalin injection into the left hind limb). Our analysis of the EEG parameters, such as EEG amplitude, amplitude differences between the left and right hemispheres, and spectral entropy showed significant pain-related effects. The responses to painful stimuli depended on the anesthesia phase.
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Perevozniuk et al. (2025) studied this question.
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