Molecular dynamics simulations reveal amino acid mutations affecting nucleotide selectivity in SARS-CoV-2 RdRp, suggesting potential for antiviral drug development.
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 (CoV2-RdRp) is a promising antiviral drug target serving for nucleotide analogue drug such as a remdesivir nucleotide analogue (RTP). In this study, based...
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