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September 5, 2025Immunological ReviewsOpen Access

Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells

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Authors

SCShuting ChenFoshan University JCJoseph CraftYale University

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Implication

Observational analysis identifies tissue t-b helper cells supporting humoral immunity in tissues, indicating distinct roles in infection and autoimmunity.

Key Points

Tissue t-b helper cells promote humoral immunity against pathogens and tumors, while also contributing to autoimmunity.
The role of t follicular helper cells in b cell maturation is complemented by tissue t-b helper cells that act outside b cell follicles.
Current knowledge highlights how t-dependent b-cell help occurs in various non-lymphoid tissues, expanding the understanding of immune responses.
Dysregulated antibody production linked to autoimmune diseases underscores the complexity of b cell maturation and humoral responses.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68bb4df56d6d5674bcd02221 https://doi.org/10.1111/imr.70056

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Implication

Observational analysis identifies tissue t-b helper cells supporting humoral immunity in tissues, indicating distinct roles in infection and autoimmunity.

Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Tissue‐Resident T Cells That Promote Humoral Immunity: Emerging From the Shadow of T Follicular Helper Cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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