Systematic Review and Meta‐Analysis of Acupuncture Treatment for Diabetic Cognitive Impairment: Focus on Animal Models

Background Cognitive impairment is a frequent complication of diabetes, yet effective treatments remain elusive. In animal models, acupuncture has shown potential in improving cognitive deficits related to diabetes, but a comprehensive evaluation of its efficacy is lacking. Materials and Methods We systematically searched seven databases (PubMed, Web of Science, Embase, OVID, SinoMed, CNKI, and Wanfang) from their inception through January 1, 2025. Studies meeting inclusion criteria underwent quality assessment using the SYRCLE Risk of Bias tool. Data analysis was conducted with Stata 14.0. Results Thirteen studies comprising 294 animals were included. Acupuncture significantly reduced blood glucose in diabetic models [SMD = −2.44, 95% CI (−3.33, −1.55); I 2 = 88.9%, p < 0.000], shortened water maze escape latency [SMD = −2.35, 95% CI (−2.86, −1.84); I 2 = 60.0%, p = 0.003], and increased target platform crossings [SMD = 1.49, 95% CI (1.10, 1.88); I 2 = 51.9%, p < 0.001]. Conclusion Acupuncture can improve cognitive impairment in diabetic animal models and lower their blood glucose levels.