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Cerebellar-limbic dysregulation and sensorimotor network alterations in male primary insomnia: a resting-state functional magnetic resonance imaging study

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Resting-state fMRI reveals altered brain connectivity in male insomnia patients, suggesting dysregulation in sensory and emotional processing.

Patients with insomnia disorder show significant alterations in cerebellar and limbic circuitry, affecting their emotional regulation.
Analysis of fMRI data indicates increased ALFF in specific brain regions, while ReHo reveals discrepancies also related to motor skills.
Both amplitudes of low-frequency fluctuations and regional homogeneity metrics do not correlate with clinical symptom severity in insomnia patients.
The findings highlight the potential of neuroimaging measures as indices for insomnia disorder, emphasizing brain connectivity more than symptoms.

Lü et al. (2025) studied this question.

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Resting-state fMRI reveals altered brain connectivity in male insomnia patients, suggesting dysregulation in sensory and emotional processing.