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September 5, 2025Frontiers in ImmunologyOpen Access

The prognostic model based on tumor-associated neutrophils contributes to the stromal landscape and influences metabolic reprogramming in colorectal cancer

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Authors

XYXinke YinYJYuanling JiangJHJinghua Huang

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Overview

Observational analysis shows that tumor-associated neutrophils influence prognosis in colorectal cancer, suggesting new stratification methods.

Key Points

  • Patients with a high-risk score exhibited significantly worse survival outcomes compared to those with a low-risk score.
  • The prognostic predictive potency of the risk score was validated with statistical significance in TCGA and GEO cohorts.
  • This observational analysis leverages single-cell RNA sequencing data to construct a risk score based on 18 TAN-associated genes.
  • The findings emphasize potential treatment implications for patients with different risk scores based on their metabolic profiles.

Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68bb4dfb6d6d5674bcd02448https://doi.org/10.3389/fimmu.2025.1587947
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