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September 5, 2025Brain and BehaviorOpen Access

Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials

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Meta-analysis shows tenecteplase improves recovery in acute ischemic stroke, indicating risks of bleeding.

Tenecteplase improves early neurological recovery and recanalization outcomes, highlighting its potential benefits.
In a meta-analysis including seven studies, tenecteplase was linked to higher rates of functional independence at 90 days.
The randomized controlled trials assessed included 3266 patients, showcasing the efficacy and safety of tenecteplase.
Although effective for recovery, tenecteplase significantly increased risks of symptomatic intracranial hemorrhage.

Bacha et al. (2025) studied this question.

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