Decoding Stroke Etiology: Multi‐Omics Advancements in Genetic Mechanisms and Clinical Implication

Purpose Stroke has a high mortality and disability rate, yet its underlying mechanisms remain not fully understood. The occurrence of stroke is influenced by a combination of environmental factors, genetic factors, and their interaction, making its pathophysiology very intricate. Finding With the development of genetic technology, researchers are endeavoring to explore the genetic risks of stroke from various perspectives, including genomics, transcriptomics, proteomics, and epigenetics, beyond common risk factors such as hypertension, diabetes, and heart disease. Conclusion These studies have produced significant findings, identifying numerous risk genes, rare variants, copy number variations, and epigenetic characteristics associated with stroke, and enhancing our understanding of stroke occurrence, progression, and prognosis, and holding great promise for advancing personalized medicine with clinical stratification and risk prediction.