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Eosinophilic hepatitis successfully treated with mepolizumab

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Case report reveals mepolizumab's role in managing eosinophilic hepatitis, suggesting it may replace corticosteroids.

Mepolizumab led to complete remission in eosinophilic hepatitis, with sustained normalization of eosinophil levels.
The patient, previously intolerant to azathioprine, successfully managed her condition without further steroid use.
Key symptoms included recurrent acute cholestatic hepatitis and severe peripheral eosinophilia.
The case highlights the need for awareness of hypereosinophilic syndrome in eosinophilic liver diseases.

Pilia et al. (2025) studied this question.

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