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September 5, 2025MedCommOpen Access

Epigenetic Regulation of Aging and its Rejuvenation

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Authors

YAYongpan AnQWQian WangKGKe Gao

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Overview

This review highlights epigenetic regulation's role in aging and explores rejuvenation strategies to counteract genomic instability and stem-cell exhaustion.

Key Points

  • Rejuvenation strategies, including CRISPR editing, aim to reset epigenetic age and promote tissue health.
  • Emerging insights into epigenetic mechanisms reveal their significant impact on age-related diseases and decline.
  • Integration of single-cell multiomics provides a roadmap for advancing personalized anti-aging medicine.
  • Understanding DNA methylation clocks and chromatin dynamics is critical for developing effective therapeutic interventions.

Cite This Study

An et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd026bchttps://doi.org/10.1002/mco2.70369
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Also Consider

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  1. 1Epigenetic Reprogramming of Aging: Reversing the Clock for Regenerative Medicine2024 · 1 citations
  2. 2Epigenetic regulation of cellular senescence2026 · 1 citations
  3. 3Partial Epigenetic Reprogramming as a Strategy for Biological Aging Reversal: Preclinical Evidence, Mechanistic Framework, and the Transition to First-in-Human Clinical Trials2026
  4. 4The evolution of aging research: from theories to epigenetic reprogramming2026
  5. 5THE DAWN OF HUMAN REJUVENATION: FROM SCIENCE FICTION TO CLINICAL REALITY : A COMPREHENSIVE REVIEW OF CELLULAR REPROGRAMMING, SENOLYTICS, AND EPIGENETIC INTERVENTIONS2026