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September 5, 2025VaccineOpen Access

Robust evaluation of vaccine effects based on estimation of vaccine efficacy curve

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The proposed method estimates vaccine efficacy over time, offering a robust and unbiased evaluation.
Simulation studies indicate problems with conventional methods and demonstrate the robustness of the Cox model framework.
The approach helps determine optimal vaccine delivery strategies, particularly in regions with seasonal disease transmission.
Comparisons of vaccine impact are now more accurate across trials with varied implementation features.

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Observational analysis of vaccine efficacy and impact in malaria trials, suggesting improved estimation methods.

Zhao et al. (2025) studied this question.

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