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September 5, 2025Journal of Digestive DiseasesOpen Access

Dynamic Relevance Between Reflux Events and Esophageal Motility in Patients With Proton Pump Inhibitor‐Refractory Gastroesophageal Reflux Disease

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Authors

SLSihui LinZWZhi Feng WangHLHua Li

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Overview

Observational study identifies significance of reflux events and esophageal motility in GERD patients, suggesting potential treatment targets.

Key Points

  • Patients with proton pump inhibitor-refractory GERD experienced longer acid reflux episodes than those responsive to treatment.
  • The number of long acid reflux episodes was notably higher in the PPI-refractory group, indicating severe esophageal motility issues.
  • Observational analysis using pH-impedance-pressure monitoring assessed reflux symptoms and motility in patients over 24 hours.
  • Findings highlight the need for alternative therapies, as ineffective peristalsis may contribute to persistent reflux symptoms.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02705https://doi.org/10.1111/1751-2980.70007
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