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September 2, 2025Open Access

Figure S3 from Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications

Sreekumar Balan Liam O’Brien Ante Peros Xuedi Wang Ingrid Leal Rojas Christopher B. McClain Kristen J. Radford Nina Bhardwaj

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Key Points

Notch signaling enhances the functionality of dendritic cells for improved cancer treatment outcomes.
Dendritic cells exposed to Notch ligand exhibit a distinct phenotype resembling their in vivo counterparts.
Analysis focuses on the impact of Notch signaling on dendritic cell generation and their potential in immunotherapy.
Findings may enable novel strategies for optimizing cancer immunotherapy using human dendritic cells.

Implication

In vitro exposure to Notch ligand alters dendritic cell phenotype, suggesting benefits for cancer immunotherapy.

Abstract

cDC1s exposed to Notch ligand during in vitro culture assume a distinct phenotype which resembles human in vivo counterparts

Discussion

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Cite This Study

Balan et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd0289f https://doi.org/10.1158/2326-6066.30028882

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications2025
2Figure S1 from Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications2025
3Figure S4 from Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications2025
4Figure S5 from Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications2025
5Figure S6 from Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy Applications2025

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