This review highlights neutrophils' role in ANCA-associated vasculitis pathogenesis, suggesting new therapeutic strategies.
The review focuses on the latest data on the role of neutrophils in the pathogenesis of ANCA-associated systemic vasculitis (AAV). Numerous signaling pathways for the regulation of neutrophil function during AAV development are discussed, including the role of neutrophil proteases, neutrophil extracellular traps, the influence of complement components and intercellular interactions. The impact of extracorporeal treatments is discussed. The perspective goals of therapy are considered.
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Beketova et al. (2025) studied this question.
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