Figure S1 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression

Key Points

Mitophagy induced by LCL768 leads to tumor suppression and depletion of fumarate.
Inhibition of mitochondrial bioenergetics was observed with LCL768, which enhances metabolic stress.
This research highlights the connection between metabolic stress and tumor suppression in cellular processes.
Understanding this relationship may pave the way for therapeutic approaches targeting mitophagy.

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Observational analysis reveals mitophagy mediates tumor suppression through metabolic stress and fumarate depletion.

LCL768 inhibits mitochondrial bioenergetics via inducing mitophagy.

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Oleinik et al. (2025) studied this question.

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