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September 5, 2025Annals of Gastroenterological SurgeryOpen Access

Response to Letter to the Editor Entitled “Clarifying Treatment Compliance and Future Directions in Perioperative Chemotherapy for Resectable Colorectal Liver Metastases”

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Authors

KSKatsunori ShinozakiTKTsuyoshi KobayashiYTYuji Takakura

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Overview

Response clarifies treatment compliance issues and future directions in perioperative chemotherapy for resectable colorectal liver metastases.

Key Points

  • The low TCR in the postoperative group is attributed to complications and treatment discontinuation after hepatectomy.
  • Current studies show no significant difference in outcomes between preoperative and postoperative chemotherapy for liver metastases.
  • The HEPATICA trial addresses postoperative adjuvant therapy effectiveness but faced challenges like premature termination.
  • Adapting molecular profiling for biologic treatment selection in colorectal cancer may face practical implementation issues.

Cite This Study

Shinozaki et al. (2025) studied this question.

synapsesocial.com/papers/68bb4e016d6d5674bcd02b04https://doi.org/10.1002/ags3.70086
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