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September 5, 2025Journal of Agricultural and Food Chemistry

Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression

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Authors

QHQingqing HanXi'an University of Architecture and TechnologyNCNan ChenJilin UniversityKPKun PengPeking University

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Implication

This study demonstrates urolithin C's effectiveness in lowering serum uric acid and protecting kidneys, highlighting its role in managing hyperuricemia.

Key Points

  • Urolithin C significantly lowered serum uric acid levels in hyperuricemia mice, indicating its effectiveness in treatment.
  • The study discovered that urolithin C reduced renal oxidative stress and fibrosis through inhibition of reactive oxygen species production.
  • Urolithin C enhanced renal uric acid excretion while targeting p38/ERK MAPK pathway, showcasing its therapeutic mechanism.
  • Results suggest urolithin C as a promising food-derived treatment option for managing hyperuricemia and renal protection.

Cite This Study

Han et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f076d6d5674bcd02c45https://doi.org/10.1021/acs.jafc.5c09146
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