Mapping the relation between trials methodology and practice-based evidence in the real world of smaller effects: Generalizability and research recommendations

Key Points

• Generalizability of trials methodology may not align with practice-based evidence in real-world settings.
• Smaller therapist effects and differential treatment effects complicate the translation of trial results.
• The study calls for improved alignment between evidence-based practice and routine therapy implementations.
• Addressing these challenges could lead to more effective therapeutic outcomes in practice.