Natural Products as Potential Anti-Tubercular Agents: In-Silico Study

Tuberculosis (TB), a severe infectious disease instigated by Mycobacterium tuberculosis, continues to pose a major public health concern worldwide. The situation is increasingly dire due to the rise of multidrug-resistant and extensively drug-resistant strains, which significantly limit the effectiveness of standard therapeutic regimens. In light of these challenges, there is a growing interest in identifying alternative treatment strategies that are both effective and sustainable. This study investigates the potential of naturally occurring compounds as promising candidates for antitubercular drug development. By employing molecular docking methods, we assess the binding affinities and interactions of selected natural products with key TB-related protein targets. The results underscore the potential of these bioactive compounds to serve as leads for the development of novel antitubercular therapies, offering a complementary approach to traditional treatment protocols and contributing to the global effort to control TB.