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September 5, 2025Open Access

Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children

Key Points

Benign transient hyperphosphatasemia is often self-limiting in children following gastroenteritis, and often resolves without intervention.
In cases examined, alkaline phosphatase levels rose post-infection but returned to normal without treatment, emphasizing the condition's benign nature.
Assessment of two cases illustrates how recognizing hyperphosphatasemia can prevent unnecessary medical investigations in otherwise healthy children.
Awareness of this self-limiting condition can significantly reduce parental anxiety and healthcare costs resulting from over-investigation.

Abstract

Serum alkaline phosphatase concentration rises in some disease states. On the other hand, benign transient hyperphosphatasemia is most commonly recognized in infants and children younger than 2 years of age. It has also been described in adults. Benign transient hyperphosphatasemia is a self-limiting condition that is usually accompanied by some infectious and allergic disorders. Therefore it is important to keep this entity in mind to avoid unnecessary investigations. Here, we report two children who were diagnosed with benign transient hyperphosphatasemia following gastroenteritis.

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Cite This Study

Yıldız et al. (Sat,) studied this question.

synapsesocial.com/papers/68bb5f266d6d5674bcd03195 https://doi.org/https://doi.org/10.33716/bmedj.1617632

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