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September 5, 2025Uludağ Üniversitesi Tıp Fakültesi DergisiOpen Access

Investigation of Drug Resistant Mycobacterium tuberculosis Strains with Molecular Methods

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Authors

APAyşe Melda PayaslıoğluSSSezcan SağlamSASeçil Ak Aksoy

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Overview

The study uncovers drug resistance mutations in Mycobacterium tuberculosis strains, indicating molecular methods may enhance treatment planning.

Key Points

  • Mutations in the rpoB and embB genes were identified in drug-resistant Mycobacterium tuberculosis strains, leading to improved treatment strategies.
  • Most common mutation detection included Ser531Leu in 10 strains, highlighting its significance in assessing rifampicin resistance.
  • Molecular analysis of 28 isolates revealed critical mutations affecting drug efficacy for tuberculosis treatment.
  • Testing conducted on 110 Mycobacterium tuberculosis isolates from Turkey between 2005 and 2014 showcases robust resistance profiling.

Cite This Study

Payaslıoğlu et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f266d6d5674bcd031a0https://doi.org/10.32708/uutfd.1723791
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