This investigation demonstrates reduced nephrotoxicity and fibrosis in rat kidney models using exosomes, suggesting potential therapeutic benefits.
Cisplatin is a widely used chemotherapeutic agent with potent antitumor activity; however, its nephrotoxicity limits clinical use, affecting 30–40% of treated patients. This study aimed to investigate the effects of mesenchymal stem cell-derived exosomes on cisplatin-induced nephrotoxicity and fibrosis in rat kidney tissue. Rats were divided into Control, Cis, Exo, and Cis+Exo groups. Nephrotoxicity was induced by a single dose Cis. Exosomes were isolated using a commercial kit and characterized by nanoparticle tracking analysis. Histopathological evaluations were performed Hematoxylin&Eosin and Periodic Acid-Schiff. Fibrosis markers were assessed by immunohistochemistry. Statistical analyses were conducted using one-way ANOVA and Kruskal-Wallis tests with Bonferroni and Dunn’s post-hoc tests, considering p
No takes yet. Share an insight, caveat, or question.
Yıldız et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: