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Mitogenomic Alterations in Breast Cancer: Identification of Potential Biomarkers of Risk and Prognosis

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Analysis identifies mtDNA variants and mutation burden linked to breast cancer risk, highlighting potential biomarkers.

Higher mtDNA mutational burden significantly correlates with increased breast cancer risk.
Cases exhibited elevated mutation levels in MT-ND5 and tRNA genes compared to controls.
Low tumor mutational burden related to worse overall survival outcomes in breast cancer patients.
Specific mtDNA variants and haplogroups may serve as meaningful biomarkers for prognosis.

Pérez-Amado et al. (2025) studied this question.

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