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September 5, 2025Open Access

Metabolic Effects of Direct-Acting Antiviral Therapy in Chronic Hepatitis C: A Focus on Glucose and Lipid Profiles

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Authors

HYHaythem YacoubSMSalma MerhabenDCDhouha Chérif

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Overview

This observational study evaluates metabolic changes in glucose and lipid profiles after DAA therapy in HCV patients, indicating potential health improvements.

Key Points

  • Post-DAA therapy, mean fasting glucose significantly decreased from 6.1 to 5.8 mmol/L, enhancing glycemic control.
  • Total cholesterol levels increased significantly post-treatment, moving from 3.8 to 4.1 mmol/L, which may affect cardiovascular risk.
  • This study included 49 patients with chronic hepatitis C who achieved sustained virological response at 12 and 48 weeks post-therapy.
  • Routine metabolic surveillance after DAA therapy is recommended, especially for patients at elevated cardiovascular risk.

Cite This Study

Yacoub et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f586d6d5674bcd03840https://doi.org/10.21203/rs.3.rs-7377090/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Direct-Acting Antiviral Therapy on Glycemic Control in Patients with Chronic Hepatitis C and Type 2 Diabetes: A Systematic Review and Meta-Analysis2026 · 2 citations
  2. 2Prospective Assessment of Serum Lipid Alterations in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals: Insights Six Months Post Sustained Virological Response2024 · 2 citations
  3. 3Longitudinal Changes in Lipid Profile After Sustained Virological Response in Patients with Chronic Hepatitis C Treated with Direct-Acting Antivirals2026
  4. 4CHANGES IN METABOLIC AND RENAL SYSTEM AFTER HCV CLEARANCE IN CHRONIC VIRAL HEPATITIS PATIENTS TREATED WITH DIRECT-ACTING ANTIVIRALS2024 · 1 citations
  5. 5Directly Acting Anti-Viral Drugs and Its Metabolic Side Effects in Patients with Chronic HCV2024