Observational analysis shows increased aldosterone reactivity in patients after weight loss, indicating changes in the renin-angiotensin-aldosterone system.
Background Weight loss after gastric bypass is associated with blood pressure reduction. However, the precise role of the sympathetic nervous system and renin-angiotensin-aldosterone system in this reduction remains unclear. We investigated the effect of RYGB-induced weight loss on the hemodynamic, hormonal, and renal responses to an orthostatic stress induced by lower body negative pressure (LBNP).
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Zahnd et al. (2025) studied this question.
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