Key result
Study examines BNP and BMI changes following Roux-en-Y gastric bypass surgery.
Why the study?
The mechanisms underlying the association of hypertension and obesity, including changes in the cardiac natriuretic peptide system after bariatric surgery, remain incompletely understood.
Observational
Truncated abstract precludes clinical application; leaves open characterization of BNP and BMI changes after Roux-en-Y bypass.
Obesity and attendant complications including type 2 diabetes mellitus, hypertension (HTN), and heart disease are worldwide epidemics with incompletely understood associations. Mechanisms underlying the association of HTN and obesity include upregulation of the renin-angiotensin-aldosterone system, sympathetic nervous system, insulin resistance, and adipose tissue activity, but a paradoxically downregulated cardiac natriuretic peptide system, cardiovascular system, and altered renal function (1). Recent studies suggest that natriuretic peptide deficiency may provide a link between obesity-related HTN and insulin resistance (2). Weight loss through bariatric surgery has reduced or eliminated HTN in multiple randomized controlled trials, perhaps through decreased plasma volume, but other mechanisms including changes in the cardiac natriuretic peptide system and lipolysis remain obscure (3). Understanding natriuretic peptide concentration changes following Roux-en-Y gastric bypass (RYGB) surgery may help elucidate the mechanism and impact of paradoxically low concentrations in obesity. We characterized changes in B-type natriuretic peptide (BNP) and N-telopeptide pro-BNP …
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Marney et al. (2014) conducted an observational in Obesity. Roux-en-Y gastric bypass surgery was evaluated on Changes in B-type natriuretic peptide (BNP) and N-telopeptide pro-BNP. The provided abstract was truncated before presenting quantitative results; the study aimed to characterize changes in B-type natriuretic peptide and BMI following Roux-en-Y gastric bypass surgery.
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