Key result
Gastric bypass predicts higher NT-proBNP in obese patients without HF, with ~22% showing elevated levels.
Why the study?
Further investigations are warranted to better characterize variables that may confound the clinical interpretation of plasma natriuretic peptide measurements in obesity.
Observational (n=206)
A substantial proportion of severely obese patients without heart failure or kidney disease have elevated NT-proBNP levels, which are inversely related to BMI and increased by prior gastric bypass surgery, potentially confounding clinical interpretation.
Authors
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Elevated NT-proBNP in obesity may confound HF diagnosis; cross-sectional data leave open causal effects of gastric bypass and optimal thresholds.
Peter et al. (2006) conducted an observational in Obesity (n=206). Gastric bypass surgery was evaluated on NT-proBNP concentrations greater than the published assay upper reference limit in patients without CHF or CKD. Among obese patients without heart failure or chronic kidney disease, 21.6% had NT-proBNP concentrations above the upper reference limit, and gastric bypass surgery predicted increased levels.
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