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September 5, 2025Veterinary SciencesOpen Access

Pharmacokinetics of Carprofen Administered Intravenously at Different Doses in Goats

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Authors

OÇOrhan ÇorumHOH. OğuzMHMustafa Hitit

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Overview

Investigation reveals pharmacokinetic differences with increasing carprofen doses in goats, indicating potential prolonged effects.

Key Points

  • At 0.7 mg/kg, carprofen exhibited a total clearance of 2.19 mL/h/kg and a half-life of 44.32 hours, indicating a moderate clearance rate.
  • Higher doses of carprofen resulted in increased total clearance and volume of distribution, suggesting dose-dependent pharmacokinetic behavior.
  • Pharmacokinetic parameters were derived using non-compartmental analysis and validated through HPLC-UV methods for accuracy.
  • Monitoring for side effects and drug residues is crucial, especially when carprofen is used repeatedly in goats.

Cite This Study

Çorum et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f586d6d5674bcd03994https://doi.org/10.3390/vetsci12090852
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