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September 5, 2025Biomolecules and BiomedicineOpen Access

Secreted frizzled-related protein 4 (sFRP4) in cancer – Dual roles in tumorigenesis and therapeutic potential: A review

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Authors

YJYu JiangFujian Medical UniversityLWLuyao WangHainan UniversityYLY. LiWeifang Maternity and Child Care Hospital

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Implication

This review highlights sFRP4's regulation of the Wnt signaling pathway in tumorigenesis, suggesting complex roles in different cancers.

Key Points

  • sFRP4 serves as both a tumor suppressor and promoter, depending on the cancer type and microenvironment.
  • Key evidence shows that sFRP4 often inhibits tumor growth by sequestering Wnt ligands and enhancing chemosensitivity.
  • This review employs a systematic literature search to analyze 47 studies featuring various cancer models and clinical data.
  • Understanding the dual roles of sFRP4 in cancer highlights the need for tailored therapeutic strategies in oncology.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68bb5f7a6d6d5674bcd03d4dhttps://doi.org/10.17305/bb.2025.13047
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Janus Face of sFRP4 in Cancer: From Mechanistic Complexity to Therapeutic Potential2026
  2. 2Abstract 584: Context-dependent roles of sFRP1 in melanoma.2026
  3. 3Identification of silibinin and isotretinoin as potent up-regulators of sFRP4 (Wnt antagonist): In silico prediction and in vitro validation in breast cancer2025 · 1 citations
  4. 4Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling2024 · 6 citations
  5. 5Secreted Frizzled-Related Protein 4 Induces Gastric Cancer Progression and Resistance to Cisplatin and Oxaliplatin via β-Catenin Dysregulation2023 · 4 citations