Catalytic asymmetric kinetic resolution of 2-ethynylaziridines via nucleophilic ring opening with amines

Wentao Ji; Tingting Cheng; Yao Li; Zhuo Chai

doi:10.1039/d5ob01270h

January 1, 2025Organic & Biomolecular Chemistry

Catalytic asymmetric kinetic resolution of 2-ethynylaziridines via nucleophilic ring opening with amines

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Key Points

Enantioselective kinetic resolution achieved, enabling the effective separation of racemic compounds.
The use of chiral Cu(I)-bisphophine led to improved selectivity in reactions with the target aziridines.
Nucleophilic ring opening with amines under this protocol demonstrates potential for broad applications in synthetic chemistry.
This efficient method highlights the importance of chiral catalysts in producing valuable chemical compounds.

Implication

Catalytic enantioselective resolution of 2-ethynylaziridines shows high efficiency, suggesting a new method for synthesizing complex molecules.

Abstract

The enantioselective kinetic resolution of racemic 2-ethynylaziridines via ring opening with amines is realized under the catalysis of a chiral Cu(I)-bisphophine combination. This protocol provides an expedient way to access...

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Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/68c182529b7b07f3a060ee1c https://doi.org/10.1039/d5ob01270h

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Catalytic asymmetric kinetic resolution of 2-ethynylaziridines via nucleophilic ring opening with amines

Key Points

Implication

Abstract

Discussion

Cite This Study

Catalytic asymmetric kinetic resolution of 2-ethynylaziridines via nucleophilic ring opening with amines

Key Points

Implication

Abstract

Discussion

Cite This Study

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