Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies

Haider Zaman; Aamer Saeed; Uzma Azam; Ghulam Shabir; Madiha Irfan; Basant Farag; Hesham R. El‐Seedi

doi:10.1039/d5ra05647k

January 1, 2025RSC AdvancesOpen Access

Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies

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Key Points

Novel guanidine derivatives demonstrate increased binding affinity to DNA minor groove, enhancing their anticancer potential.
Spectroscopic and DFT studies indicate that electron-donating groups synergize with halogens to improve binding effectiveness.
This study uses synthetic methods to create guanidines, revealing their promising applications as anticancer agents.
The findings suggest guanidine scaffolds could provide new strategies in anticancer drug discovery and development.

Implication

Synthesis shows enhanced binding affinity in DNA minor groove, implying potential for anticancer drug design.

Abstract

Novel guanidines are synthesized as DNA minor groove binders. Spectroscopic and DFT studies revealed that EDGs synergize with halogens to enhance binding affinity, offering promising scaffolds for anticancer drug design.

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Cite This Study

Zaman et al. (2025) studied this question.

synapsesocial.com/papers/68c182589b7b07f3a060ef5c https://doi.org/10.1039/d5ra05647k

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Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel guanidine derivatives as mechanistic scaffolds for anticancer agents: synthesis, characterization, DNA-binding, and computational studies

Key Points

Implication

Abstract

Discussion

Cite This Study

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