Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains

Zixuan Gao; W. HAO; Jinming Liu; Kejian Li; Yin–Xia Sun; Xudong Wu; Zirui Luo; Rui Liu; Haoyu Zhang; Nian Liu; Dongmei Zhao; Maosheng Cheng

doi:10.1039/d5md00632e

January 1, 2025RSC Medicinal Chemistry

Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains

View at Publisher

Ask AI

Bookmark

Share

Key Points

The compound YW-01 demonstrates potent antifungal activity against Candida albicans, suggesting effective treatment options.
With a unique structural design, YW-01 acts as a CYP51 inhibitor, crucial for fungal growth.
The synthesis of amide imidazole compounds offers innovative alternatives to combat invasive fungal infections.
These findings support the need for new antifungal strategies to address rising threats from invasive fungal infections.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Novel CYP51 inhibitors show antifungal activity against Candida albicans, highlighting potential new treatment options.

Abstract

Invasive fungal infections caused by Candida albicans are becoming increasingly severe, creating an urgent need to explore new antifungal drugs. Compound YW-01 is a structurally novel CYP51 inhibitor that was...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c182589b7b07f3a060f0d2 https://doi.org/10.1039/d5md00632e

View at Publisher

Ask AI

Bookmark

Share

Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading