The Association between Coagulation Indices and Mortality in Critically Ill Patients with Atrial Fibrillation: A Retrospective Study

Background There is no cumulative evidence supporting the role of coagulation indices in mortality among the critically ill patients with atrial fibrillation (AF). Methods The data were derived from the MIMIC-III database, which included a total of 2284 individuals. We explored the association between coagulation indices and mortality using multivariable correction analysis. Results 2284 participants were included in the study with a median age of 71.29, and 1476 participants were male (64.62%). The median levels of coagulation indices -PTT, PT, INR PT and fibrinogen were 44.14 s, 16.95 s, 1.67 and 277.8 mg/dL, respectively. After adjusting for confounding factors, there were still strong positive correlations between coagulation indices and mortality (hospital mortality, 7-day mortality, 30-day mortality, and 1-year mortality), (all P < 0.001). In addition, stratified analysis showed that gender as a covariate affected the association between PTT and mortality; age, valvular disease, statins, heparin and aspirin were covariates that affected the association between fibrinogen and mortality Conclusions Our study is the first to indicate that there is a positive correlation between coagulation indices (PTT, PT/INR PT, fibrinogen) and mortality in critically ill patients with AF.