Figure 5 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Q: What type of study is this?

This is a In Vitro Study study (also classified as: Animal Study).

Beatriz Parejo-Alonso; David Barneda; Sara Maria David Trabulo; Sarah Courtois; Sara Compte-Sancerni; Jelena Zurkovic; Laura Ruíz-Cañas; Quan Zheng; Jiajia Tang; Matthias M. Gaida; Ulf Schmitz; Pilar Irún; Laure Penin-Peyta; Shanthini Mary Crusz; Petra Jagušt; Pilar Espiau-Romera; Alba Royo-García; Andrés Gordo-Ortiz; Mariia Yuneva; Meng‐Lay Lin; Shenghui Huang; Ming-Hsin Yang; Ángel Lanas; Bruno Sáinz; Christoph Thiele; Christopher Heeschen; Patricia Sancho

doi:10.1158/0008-5472.30029489

Key Points

Targeting PPARδ impacts both glycolysis and OXPHOS, linking metabolic regulation to metastasis.
Evidence from assays shows that inhibition of PPARδ alters cell invasion patterns in PDAC cells.
The methodology involved in vitro and in vivo approaches using pancreatic cancer cell lines and mouse models.
Findings support further investigation into metabolic therapies targeting PPARδ in pancreatic cancer.

Implication

Observational analysis highlights the role of PPARδ in regulating glycolysis and invasion in pancreatic cancer, suggesting potential therapeutic targets.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Parejo-Alonso et al. (2025) studied this question.

synapsesocial.com/papers/68c183f09b7b07f3a060f735 https://doi.org/10.1158/0008-5472.30029489

View Full Paper

Ask AI

Bookmark

Share

Figure 5 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure 5 from PPARδ Orchestrates a Prometastatic Metabolic Response to Microenvironmental Cues in Pancreatic Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading