Bridging the Neural and the Numinous

Once central to countercultural spirituality and mystical exploration, psychedelics have been rebranded in Silicon Valley as tools for optimization, productivity, and cognitive control. This study examines how tech elites and aspirants are reconfiguring psychedelic practice under the influence of TESCREAL—an ideological bundle of Transhumanism, Extropianism, Singularitarianism, Cosmism, Rationalism, Effective Altruism, and Longtermism. Framed by Timnit Gebru and Émile Torres as a secular religion of technological salvation, TESCREAL advances a worldview that sacralizes rationalization, control, and the conquest of natural limits. Within this paradigm, psychedelics shift from sacraments of surrender to instruments of technocratic self-mastery. Methodologically, this study draws on discourse analysis of media coverage, cultural texts, and case studies including Bryan Johnson’s Project Blueprint, Michael Pollan’s reframing of psychedelics as medicine, Elon Musk’s advocacy of psychedelics as tools for leadership and empathy, and ventures such as Mindstate Design Labs, which aim to engineer “programmable mystical states.” These examples reveal how Silicon Valley translates ineffable experiences into measurable, replicable, and marketable states. This analysis introduces the term post-mysticality to describe this development. Post-mysticality refers to the process by which mystical experiences are standardized into predictable protocols for capitalist utility, aligning with neoliberal imperatives of efficiency, longevity, and cognitive enhancement. Psychedelics thus become folded into a larger TESCREAL project of technological transcendence, where the unknown is treated as a problem to be solved rather than a mystery to be encountered. This study contributes to the fields of religious studies, science and technology studies, and consciousness research by showing how Silicon Valley’s evolving psychedelic culture reflects a broader epistemic and metaphysical transition of normalizing optimization as a cultural value and extending biopolitical governance into the realm of inner experience. The findings raise critical questions about whether psychedelics will foster expanded consciousness and social imagination, or instead become another frontier colonized by code, capital, and control.