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September 10, 2025Renal FailureOpen Access

Investigating the genetic effects of metformin-related targets on IgA nephropathy using Mendelian randomization

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Authors

YZYan ZhangJLJinyan LinPZPeizhuang Zheng

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Overview

Mendelian randomization reveals potentially protective effects of metformin targets on IgA nephropathy, implying novel therapeutic targets.

Key Points

  • A significant association found between ETFDH inhibitors and a reduced risk of IgA nephropathy.
  • Inverse variance weighted analysis showed ETFDH inhibitors reduced IgAN risk with an odds ratio of 0.948.
  • Mendelian randomization analysis identified 420 protective plasma proteins linked to ETFDH inhibitors.
  • Identifying synaptosome-associated protein 29 as a risk factor underscores its mediating role in IgAN.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c183f89b7b07f3a060fe57https://doi.org/10.1080/0886022x.2025.2553843
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