Rh(III)-Catalyzed Cascade Cyclization of Enaminones with Diazo compounds: Switchable Syntheses of 2-Pyrones and Pyrido-quinazolinones

Hong-Xiang Huang; Ruimeng Zhang; Leiqing Fu; Jie‐Ping Wan

doi:10.1039/d5qo01086a

January 1, 2025Organic Chemistry Frontiers

Rh(III)-Catalyzed Cascade Cyclization of Enaminones with Diazo compounds: Switchable Syntheses of 2-Pyrones and Pyrido-quinazolinones

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Key Points

Cascade cyclization results in good yields of 2-pyrones and pyrido-quinazolinones, highlighting synthetic versatility.
Rh(III) catalysis enables C−H activation of enaminones, optimizing reaction conditions across varied substrates.
The methodology involves diazo compounds, expanding the range of possible synthetic routes and applications.
This research supports switchable synthesis, indicating potential for different target compounds with minor modifications.

Implication

Rh-catalyzed cyclization constructs 2-pyrones and pyrido-quinazolinones, suggesting versatile synthetic methods.

Abstract

The Rh-catalyzed C−H activation of N-pyridinyl enaminones and cascade cyclization with diazo compounds are reported to construct 2-pyrones and pyrido-quinazolinones with a broad range of substrates and good yields. The...

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Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c184069b7b07f3a061040b https://doi.org/10.1039/d5qo01086a

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Rh(III)-Catalyzed Cascade Cyclization of Enaminones with Diazo compounds: Switchable Syntheses of 2-Pyrones and Pyrido-quinazolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

Rh(III)-Catalyzed Cascade Cyclization of Enaminones with Diazo compounds: Switchable Syntheses of 2-Pyrones and Pyrido-quinazolinones

Key Points

Implication

Abstract

Discussion

Cite This Study

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