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September 10, 2025International Journal of experimental research and review

Decoding the HPV-Positive HNSCC Paradox: Suppression of Oncogenic Drivers and Inflammatory Signalling Creates a Distinct Tumor Microenvironment

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Authors

MMM. MondalDRDivyadarshi RaiPCPratiksha Chhetri

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Overview

Integrated analyses reveal decreased oncogenic drivers and inflammatory signalling in HPV-positive HNSCC, suggesting better prognosis.

Key Points

  • HPV-positive HNSCC shows reduced oncogenic drivers and inflammatory signals, leading to better survival outcomes.
  • Expression levels of key genes such as MMP1 and IL1 are significantly higher in HPV-negative tumors, indicating aggressive behavior.
  • Transcriptomic and epigenomic analyses highlight chromatin regulation changes, reinforcing epithelial survival pathways in HPV-positive tumors.
  • The unique biological properties of HPV-positive HNSCC offer insights into its distinct prognosis compared to HPV-negative cases.

Cite This Study

Mondal et al. (2025) studied this question.

synapsesocial.com/papers/68c184069b7b07f3a06104e4https://doi.org/10.52756/ijerr.2025.v48.001
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