This review highlights the significance of Na,K-ATPase as an ion pump in lung diseases, suggesting it as a potential therapeutic target.
Na,K‑ATPase, commonly referred to as the sodium pump, is known for its essential function as an ion pump, which is key for transporting Na⁺ and K⁺ across plasma cell membranes. Additionally, Na,K‑ATPase has multiple biological functions, independent of ion pumping, which are involved in regulating cell proliferation, apoptosis, differentiation and other processes associated with the development and progression of various diseases; particularly cancer, cardiovascular diseases, nervous system diseases, kidney diseases and lung diseases. As a potential therapeutic target, Na,K‑ATPase may represent a novel strategy for treating these diseases in the future. The present review aims to summarize the role of Na,K‑ATPase in lung diseases.
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Liu et al. (2025) studied this question.
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