Effectiveness of 2024–2025 COVID-19 Vaccination Against COVID-19 Hospitalization and Severe In-Hospital Outcomes — IVY Network, 26 Hospitals, September 1, 2024–April 30, 2025
Test-negative case-control analysis estimates COVID-19 vaccine effectiveness against hospitalization, indicating sustained protection over time.
Key Points
COVID-19 vaccine effectiveness was found to be 40% against hospitalization, with higher rates for severe outcomes like IMV or death at 79%.
In total, 1,888 COVID-19 cases and 6,605 controls were analyzed, considering demographics and clinical characteristics.
Logistic regression was employed to compare vaccination odds in cases versus controls, with results supporting ongoing vaccine effectiveness over time.
The findings emphasize that 2024–2025 COVID-19 vaccines offer additional protection as different JN.1 lineages continue to circulate.