Evaluating a Digital Chronic Condition Prevention Intervention (THRIVE) in Australian General Practice: Protocol for a Mixed Methods Feasibility Study (ePREVENT-360) (Preprint)

BACKGROUND Chronic conditions are responsible for a growing burden of morbidity, mortality, and cost globally. Despite widespread recognition of the need for preventive care, general practice remains under-resourced and focused primarily on treatment. Digital health interventions (DHIs) present a scalable solution to support person-centred preventive care, but evidence of feasibility and acceptability of multi-risk consumer facing interventions in general practice remains limited. OBJECTIVE This study (ePREVENT-360) aims to evaluate the feasibility, acceptability, sustainability, and preliminary impact on health activation of a consumer-facing DHI (THRIVE) in Australian general practices. METHODS A mixed-method, pre-post feasibility study will be conducted in five general practice clinics across New South Wales, Queensland, and Victoria. Adult consumers aged 30–65 years will use the THRIVE digital platform, which delivers personalized chronic condition risk assessments, health scores, and action plans. Quantitative data will include engagement metrics, surveys, and chronic condition risk scores. Qualitative semi-structured interviews with consumers and clinicians will provide data about acceptability, engagement, and sustainability. Quantitative data will be analyzed using descriptive and multilevel regression methods, while qualitative data will be analyzed thematically. RESULTS The study has received human research ethics approval (approval no 2024-274) and secured funding through a XXXX Research Grant. Recruitment is scheduled to commence in September 2025. Outcomes will inform iterative intervention refinement and future trial design to measure effectiveness. CONCLUSIONS This study will address a key evidence gap in the digital prevention space by evaluating feasibility, acceptability, and sustainability of a multi-condition DHI embedded in general practices. Findings will support development of a larger adaptive controlled trial and inform future implementation. CLINICALTRIAL Australian and New Zealand Clinical Trials Registry 12624001174572; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12624001174572p (25/9/24). This protocol is reported according to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines 2025.1 The SPIRIT checklist is provided in Supplementary File 1.