This research demonstrates high enantioselectivity in asymmetric hydrogenation of nitrogen heterocycles, suggesting broad potential applications.
Using the chiral NNP-manganese complex as catalyst, asymmetric hydrogenation of multi-nitrogen aromatic heterocycles including 5- or 7-substituted pyrazolo[1,5-a]pyrimidines, pyrrolo[1,2-a]pyrazines, and imidazo[1,2-a]pyrazines has been successfully developed, providing the corresponding reductive products with high enantioselectivity, reactivity, and wide substrate scope.
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Liu et al. (2025) studied this question.
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